We turn poorly soluble compounds into bioavailable therapeutics
Most small-molecule drug candidates are too poorly water-soluble for reliable oral bioavailability. We solve that through rigorous formulation design and development.
Trusted by biotech and pharma innovators
Technologies
We select the solubility-enhancing technology based on your compound's physicochemical and biopharmaceutical profile, not on what we happen to sell.
Spray-dried dispersions that hold drug in a high-energy amorphous state.
Drug particles milled to the sub-micron range.
Water-miscible formulations that present the drug in pre-dissolved form to the gastrointestinal fluids.
Lipid-rich formulations that sequester the compound, preventing precipitation on dilution in the gut.
Why Harpago?
Experts in solubility enhancement for small-molecule therapeutics
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Specialists, not generalists
Solubility enhancement is all we do. That focus lets us solve formulation problems generalist CDMOs walk away from.
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More science, less overhead
We're built for early-phase R&D, not big-plant manufacturing — so you pay for specialist formulation expertise, not for a factory you'll never use.
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Straight to the experts
No layers, no hand-offs. You work directly with our scientists, so answers and decisions come quickly.
Services
We characterise your compound in detail, design the formulation that makes it bioavailable and supply formulation in support of your discovery and preclinical studies.
Designing formulations that make your poorly soluble compound bioavailable.
Manufacturing your formulation at litre/kilogram scale for preclinical studies.
Characterising your API's physicochemical and biopharmaceutical properties, so formulation decisions rest on data.