Preformulation
Prior to embarking on a formulation design program, we analyse the API for its physicochemical, biopharmaceutical, particulate and bulk properties. In doing so, we adhere to our philosophy of phase-appropriateness, meaning we collect increasingly detailed information as a compound progresses through development.
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API-sparing
Our miniaturized protocols enable the collection of detailed information while consuming only mg-quantities of API
Phase-appropriate
We work closely with our customers to understand their needs and collect the right data at the right time.
Rapid turnaround
Our agility and specialization enable us to work faster than generalist CDMOs. No work package is too small for us.
Our preformulation services
- PhysicochemicalSolid form screening and selection
Solubility
pKa
Log P
Melting point
Chemical stability
(heat, oxidation, light, pH)
Hygroscopicity - BiopharmaceuticalSolubility in biorelevant fluids
Stability in biorelevant fluids
Dissolution rate
Permeability
Metabolic stability - Particulate and bulkParticle size
Particle morphology
Flow properties
Density
Compressibility
Wettability
Excipient compatibility
Project consultation
If you would like to learn more about our preformulation services, you can reach out to one of our experts here. We are happy to make a gap analysis of your current preformulation data package and suggest appropriate follow-up experiments to inform your formulation development project.