Administration of the API as a solution bypasses the dissolution step and presents the API directly in predissolved form to the gastrointestinal fluids which creates a high driving force for absorption. The criticality of using solution formulations for poorly water-soluble APIs is to inhibit API precipitation on in-vivo dilution for long enough to allow for absorption to occur. This may be achieved via the addition of precipitation inhibitors to the formulation. Another challenge is to achieve a high enough payload in the formulation such that the target dose can be delivered with an acceptable volume of formulation. Our miniaturized screens allow us to identify combinations of excipients that offer synergistic effects on solubilization while consuming only mg-quantities of API.