Reducing particle size is the easy part. Keeping it small is the challenge.
Without the right stabilisers, nanocrystals grow through Ostwald ripening or aggregation, and the dissolution advantage is lost. We specialise in designing physically stable nanosuspensions, selecting stabiliser systems tailored to your API's surface properties to preserve particle size from milling through to dosing.
We select steric and electrostatic stabilisers matched to your API's surface chemistry to prevent aggregation, Ostwald ripening and sedimentation.
Ultra-rapid dissolution
Nanosized particles dramatically increase surface area, so your API dissolves within seconds in gastrointestinal fluids.
Phase-appropriate
Simple, stable nanosuspensions for early studies, with a clear route to solid dosage forms by spray drying or bead coating as your programme progresses.